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Multi scale topography in titanium alloys by electron beam technique: influence on the tissue adhesion and bacterial contamination

Part of:
- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
- Poster Corrosion behaviour of potencially biodegradable ternary alloy Zn-Mg-Ca 1 Dipl.-Ing. Jan Pinc
- Poster Multi scale topography in titanium alloys by electron beam technique: influence on the tissue adhesion and bacterial contamination 1 Dr. Fernando Warchomicka
- Poster Cytotoxicity of gold nanorods and nanoribbons in context of biomedical applications 1 Marika Musielak
- Poster Preliminary studies of synthesis of gold nanoribbons using selected dicationic surfactants 1 Joanna Patalas
- Poster Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating 1 Prof. Ana Serro
- Poster Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s 1 Mengshi Yang
- Poster Influence of Cu2+-doping in β-TCP on the hydration kinetics of brushite cement investigated by Rietveld analysis and heat flow calorimetry 1 Karla Späth
- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
- Poster Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations 1 Berit Karl
- Poster Graded functionalization of polydopamine coated fiber mats as potential implant for tendon-bone-transition 1 Sarah Oehmichen
- Poster Enhancing the functionalities of bioactive glass-based scaffolds by novel polymeric coatings 1 Dr. Liliana Liverani
- Poster Durability analysis of the cryopreservation of DNA origami nanostructures 1 Yang Xin
- Poster Effects of staple age on DNA origami nanostructure assembly and stability 1 Charlotte Kielar
- Poster Dual-setting brushite-silica gel cements – Variations of the monomer precursors and tuning of the setting parameters 1 Ib Holzmeister
- Poster Novel QCM-D/microscopy set-up for real-time analysis of bacterial binding onto biomaterial-coated sensors 1 Dr. Zeqian Xu
- Poster Chairside plasma activation of encapsulated implants: how fast is it? 1 Miguel Angel Garcia Chame
- Poster Nanostructured high-pressure laminate surfaces to reduce transmission pathways of pathogens in public transportation 1 Christian Helbing
- Poster Biomineralization of Recombinant Spider Silk Films 1 Vanessa J. Neubauer
- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
- Poster Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications 1 Mandy Grube
- Poster Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human body 1 Zaneta Górecka
- Poster Nano-rough titanium surfaces created by wet alkaline etching and PVD and their influence on bacterial adhesion as well as protein adsorption 1 Michaela Schürmann
- Poster Effective strategies for the controlling and dealing with transmission pathway of pathogens in air traffi 1 Christian Helbing
- Poster Cytotoxicity evaluation of biodegradable Zn-4Cu alloy using L929, Saos-2 and TAg cell lines 1 Ping Li
- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

Session P: Poster Session
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Topographical surface modification in implants is an interesting topic of investigation to improve the tissue regeneration. Different cell types preferentially adhere to specific topographies. In the case of osteoblast cells, a rough surface improves the adherence and spreading of the cells, while fibroblasts are more sensitive to micro-surface patterns. Electron beam structuring has the potential to serve as a technique for controlling the surface topography as well as for increasing the tribological behavior on the surface of titanium alloys. This works shows examples of surface design in three different titanium alloys and the effect of the multi scale topography on the adherence, spreading and alignment of different cells and the bacterial adhesion. The in vitro investigations reveal a positive cell behavior on all structured titanium alloys for each cultivation time. The osteoblastic cells are even distributed with a polygonal morphology and build connections through elongated actin filaments, with significant increase of cell spreading area on surface structure with a finer canal shape in polygonal figures. Aligned and parallel micro grooves of 10 and 30µm wide show positive effect on fibroblast, with strong alignment of the cells in 10µm grooves. Bacterial reduction in the first 48hs is observed and it might be related to microstructural features of the material on the surface.

On the other hand, the heat input given during the structuring modifies the microstructure of the material, observing an increment of the hardness by martensite formation in cp TiGr2 and Ti-6Al-4V and metastable phases with fine dispersed alpha grains in Ti15Mo .

Dr. Fernando Warchomicka
Graz University of Technology
Additional Authors:
  • Dr. Claudia Ramskogler
    Graz University of Technology
  • Dr. Sara Ferraris
    Politecnico di Torino
  • Dr. Andrea Cochis
    Università del Piemonte Orientale
  • Prof. Dr. Lia Rimondini
    Università del Piemonte Orientale
  • Prof. Dr. Annelie Weinberg
    Medical University Graz
  • Prof. Dr. Silvia Spriano
    Politecnico di Torino
  • Prof. Dr. Christof Sommitsch
    Graz University of Technology