Tribology is the science of interacting surfaces in relative motion. Understanding the behavior of biological interfaces as well as interfaces between medically engineered products and biological matter can be of interest for medical research and product development. Contact between the eye lid and the cornea, articular cartilage, catheters, implants, are a few examples of such scenarios. These systems are characterized by the properties of the respective surfaces, the fluids involved, as well as the dynamic characteristics at the interface, such as speed, normal and tangential forces, etc. The dynamic behavior of the tribosystems can be investigated experimentally by model-scale testing. The authors here present as to how one can set up tribological tests with biological material and biomimetic materials. This includes, choice of proper specimen, adaptation of existing test equipment for biomaterial testing, and designing an appropriate test routine. Results from tribological studies are presented in the form of extended Stribeck curve and breakaway torque measurements.