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Oral Poster

Optimization of a calcium phosphate based bone cement formulation

Part of:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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Calcium phosphate cements (CPCs) have been increasingly used for bone grafting due to their biocompatibility and rapid osteointegration. Neocement is a commercial CPC whose setting is initiated by adding 38% of a liquid phase (LP) to a solid phase composed by two calcium phosphate types and a small amount of chitosan. In this work, the effect of changing the proportion of the liquid phase and chitosan content on the biomechanical properties and handling performance of this CPC was investigated.

Samples with different proportions of liquid phase (LP 30%, 38%, 42% and 50%) were prepared. Additionally, for LP 38%, formulations without chitosan or with half of its base concentration were studied.

The increase of the LP content from 30% to 50% led to an increase in the initial setting time from 6.5 min to 24 min, and in the final setting time from 7.5 min to 32 min. Moreover, varying the amount of chitosan did not alter the setting times significantly. Mechanical properties were evaluated after setting for 6 days. Concerning the resistance to compression, the increase in LP content to 50% lowered this parameter from 9.5 to 0.8 MPa. The materials hardness decreased about 70% when moving from 30% to 50% LP. For both properties, the effect of the chitosan content was less significative than the one of LP. Injectability measures showed that all formulations could be injected except LP 30%.

The obtained results demonstrate that for LP42% the resistance to compression and hardness of the materials assume suitable values for their use as bone defect fillers with adequate setting times for application in reachable trabecular bone defects. Nevertheless, only samples with 38% and 42% LP present good injectability. Although chitosan content did not affect significantly the analyzed properties, further studies are needed to evaluate its influence in improving osteoinduction.


Prof. Dr. Rogério Cola?o
Instituto Superior Técnico
Additional Authors:
  • Marta Reis
    Instituto Superior Técnico
  • Dr. Nuno Ribeiro
    Hospital dos Lusiadas
  • Dr. Lígia Figueiredo
  • Dr. Andreia Pimenta
  • Prof. Dr. Ana Serro
    Instituto Superior Técnico