Download program brochure

Back to overview


Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating

Part of:
- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
- Poster Corrosion behaviour of potencially biodegradable ternary alloy Zn-Mg-Ca 1 Dipl.-Ing. Jan Pinc
- Poster Multi scale topography in titanium alloys by electron beam technique: influence on the tissue adhesion and bacterial contamination 1 Dr. Fernando Warchomicka
- Poster Cytotoxicity of gold nanorods and nanoribbons in context of biomedical applications 1 Marika Musielak
- Poster Preliminary studies of synthesis of gold nanoribbons using selected dicationic surfactants 1 Joanna Patalas
- Poster Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating 1 Prof. Ana Serro
- Poster Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s 1 Mengshi Yang
- Poster Influence of Cu2+-doping in β-TCP on the hydration kinetics of brushite cement investigated by Rietveld analysis and heat flow calorimetry 1 Karla Späth
- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
- Poster Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations 1 Berit Karl
- Poster Graded functionalization of polydopamine coated fiber mats as potential implant for tendon-bone-transition 1 Sarah Oehmichen
- Poster Enhancing the functionalities of bioactive glass-based scaffolds by novel polymeric coatings 1 Dr. Liliana Liverani
- Poster Durability analysis of the cryopreservation of DNA origami nanostructures 1 Yang Xin
- Poster Effects of staple age on DNA origami nanostructure assembly and stability 1 Charlotte Kielar
- Poster Dual-setting brushite-silica gel cements – Variations of the monomer precursors and tuning of the setting parameters 1 Ib Holzmeister
- Poster Novel QCM-D/microscopy set-up for real-time analysis of bacterial binding onto biomaterial-coated sensors 1 Dr. Zeqian Xu
- Poster Chairside plasma activation of encapsulated implants: how fast is it? 1 Miguel Angel Garcia Chame
- Poster Nanostructured high-pressure laminate surfaces to reduce transmission pathways of pathogens in public transportation 1 Christian Helbing
- Poster Biomineralization of Recombinant Spider Silk Films 1 Vanessa J. Neubauer
- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
- Poster Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications 1 Mandy Grube
- Poster Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human body 1 Zaneta Górecka
- Poster Nano-rough titanium surfaces created by wet alkaline etching and PVD and their influence on bacterial adhesion as well as protein adsorption 1 Michaela Schürmann
- Poster Effective strategies for the controlling and dealing with transmission pathway of pathogens in air traffi 1 Christian Helbing
- Poster Cytotoxicity evaluation of biodegradable Zn-4Cu alloy using L929, Saos-2 and TAg cell lines 1 Ping Li
- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

Session P: Poster Session
Belongs to:

Soft contact lenses (SCLs) constitute a promising vehicle for ocular drug delivery due to their biocompatibility, prolonged contact with the eye and general acceptance. Soaking in the drug solution is the simplest method to load the drug into the SCLs. However, by itself, it usually does not allow ensuring a controlled drug release, compatible with the therapeutic needs. Thus, additional approaches, such as the application of coatings on the SCLs, have been tried to achieve that purpose.

In this work, a lab-made silicon based hydrogel intended for SCLs was loaded by soaking with an anti-inflammatory drug (diclofenac, DCF) and coated, using a layer-by-layer (LbL) coating strategy, with alginate, chitosan and hyaluronic acid (ALG/CHI/HA). Material properties such as transmittance, wettability, ionic permeability and swelling were studied. In all cases, the material presented adequate characteristics to be used in therapeutic SCLs. Drug release experiments were carried out under sink conditions. The results demonstrated that DCF release can be regulated by the coating. A mathematical model was applied to predict the in vivo efficacy of the coated lenses, indicating that the studied system may ensure a controlled release of the drug within therapeutic levels for more than 2 weeks. Chorioallantoic membrane (HET-CAM) tests suggest that the coated material shall not induce ocular irritation.

The interaction of lysozyme (one of the most abundant protein in lacrimal fluid) with the coating was evaluated by quartz-crystal microbalance with dissipation (QCM-D). It was concluded that the coating has an antifouling properties.

In sum, the LBL coating of the DCF loaded silicon based hydrogel is pointed out as an efficient strategy to get efficient therapeutic SCLs, without impairing relevant properties for the intended application.

Prof. Ana Serro
Instituto Universitário Egas Moniz
Additional Authors:
  • Diana Silva
    Instituto Superior Técnico
  • Prof. Hermínio Sousa
    Universidade de Coimbra
  • Prof. Helena Gil
    Universidade de Coimbra
  • Prof. Carmen Alvarez-Lorenzo
    Universidade de Santiago de Compostela
  • Prof. Benilde Saramago
    Instituto Superior Técnico