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Oral Poster

Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis

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18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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Cataract affects more than 20 million people worldwide each year and is the major cause of visual impairment. Its treatment implies the removal of the opacified natural lens and its substitution by an intraocular lens (IOL). Post-operatory complications, such as endophthalmitis, are usually prevented through the topical application of eyedrops containing antibiotic and anti-inflammatory. Such drug delivery method may lead undesirable side effects, low bioavailability of the drug and low patient compliance.

In this work, the possibility of using IOLs as platforms for the simultaneous delivery of both types of drugs is explored. An antibiotic (moxifloxacin (MXF)) and an anti-inflammatory (diclofenac (DFN)) were loaded in acrylic IOLs by soaking in the drugs solutions. Loading was carried out in two ways: in a solution containing MXF+DFN, and sequentially in solutions containing just one of the drugs. The loaded lenses were autoclaved and submitted to in vitro drug release experiments were carried out in sink conditions. Relevant properties for the IOLs performance, such as the swelling capacity, optical properties (transmittance) and mechanical properties (Young’s modulus), were investigated.

The results show that the double loaded lenses released an higher amount of MXF than the single loaded lenses, while for DFN no difference was observed. Sterilization did not affect the release. The application of a mathematical model, that takes into account the volume and renovation rate of the aqueous humour, suggests that these devices are able to release effective amounts of the drugs for 2-4 weeks. The presence of drugs increases the swelling capacity of the lenses. Changes in optical and mechanical properties do not compromise the use of the lenses.

In sum, the sterilized double loaded lenses seem to be promising devices for the endophthalmitis prophylaxis, complying with both antibiotic and anti-inflammatory therapeutic needs.

 

Speaker:
Prof. Ana Serro
Instituto Universitário Egas Moniz
Additional Authors:
  • Prof. Benilde Saramago
    Instituto Superior Técnico
  • Ana Topete
    Instituto Universitário Egas Moniz