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Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications

Part of:
- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
- Poster Corrosion behaviour of potencially biodegradable ternary alloy Zn-Mg-Ca 1 Dipl.-Ing. Jan Pinc
- Poster Multi scale topography in titanium alloys by electron beam technique: influence on the tissue adhesion and bacterial contamination 1 Dr. Fernando Warchomicka
- Poster Cytotoxicity of gold nanorods and nanoribbons in context of biomedical applications 1 Marika Musielak
- Poster Preliminary studies of synthesis of gold nanoribbons using selected dicationic surfactants 1 Joanna Patalas
- Poster Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating 1 Prof. Ana Serro
- Poster Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s 1 Mengshi Yang
- Poster Influence of Cu2+-doping in β-TCP on the hydration kinetics of brushite cement investigated by Rietveld analysis and heat flow calorimetry 1 Karla Späth
- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
- Poster Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations 1 Berit Karl
- Poster Graded functionalization of polydopamine coated fiber mats as potential implant for tendon-bone-transition 1 Sarah Oehmichen
- Poster Enhancing the functionalities of bioactive glass-based scaffolds by novel polymeric coatings 1 Dr. Liliana Liverani
- Poster Durability analysis of the cryopreservation of DNA origami nanostructures 1 Yang Xin
- Poster Effects of staple age on DNA origami nanostructure assembly and stability 1 Charlotte Kielar
- Poster Dual-setting brushite-silica gel cements – Variations of the monomer precursors and tuning of the setting parameters 1 Ib Holzmeister
- Poster Novel QCM-D/microscopy set-up for real-time analysis of bacterial binding onto biomaterial-coated sensors 1 Dr. Zeqian Xu
- Poster Chairside plasma activation of encapsulated implants: how fast is it? 1 Miguel Angel Garcia Chame
- Poster Nanostructured high-pressure laminate surfaces to reduce transmission pathways of pathogens in public transportation 1 Christian Helbing
- Poster Biomineralization of Recombinant Spider Silk Films 1 Vanessa J. Neubauer
- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
- Poster Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications 1 Mandy Grube
- Poster Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human body 1 Zaneta Górecka
- Poster Nano-rough titanium surfaces created by wet alkaline etching and PVD and their influence on bacterial adhesion as well as protein adsorption 1 Michaela Schürmann
- Poster Effective strategies for the controlling and dealing with transmission pathway of pathogens in air traffi 1 Christian Helbing
- Poster Cytotoxicity evaluation of biodegradable Zn-4Cu alloy using L929, Saos-2 and TAg cell lines 1 Ping Li
- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

Session P: Poster Session
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Nanomaterials play an important role in our daily life and have become essential in the areas of medicine and pharmaceutical applications, often in connection to biomaterials. Advanced synthetic approaches offer the creation of such materials while tailoring their macromolecular size. Our research focuses on the fundamental characterization of such macromolecules in connection to their purpose in the life sciences by a quantitative description of their behavior in solution associated to absolute values of the molar mass, molecular solvation, and overall (hydrodynamic) size.

The synthetic gold standard in medical implementations are poly(ethylene glycol)s (PEG), because of their stealth effect toward the immune system, associated with low toxicity and noticed biocompatibility. An intense use of PEG in common commodity applications such as salves, creams, and in drug conjugation resulted in recent reports of antibodies. Therefore, alternatives, e.g. poly(2-oxazoline)s (POx) are more strongly coming into the focus of research.

Here, we present the solution characterization of PEG and its alternative POx, for use in biomaterial-related settings. We utilize two macromolecular characterization techniques in solution for such purpose, i.e. hydrodynamic analysis via viscometry and sedimentation-diffusion analysis as well as fractionation / separation techniques coupled to multi-angle laser light scattering (MALLS). The use of a hydrodynamic invariant concept comprises sedimentation, diffusion / molar masses, and intrinsic viscosity of the same macromolecule populations. This concept was used to achieve a quantitative interrelation of the results of experimentally different methods for macromolecule characterization.

We found that both PEG and POx assume a random coil conformation in solution. Interestingly, both macromolecules show the same hydrodynamic interrelation of parameters, though absolute values of individual hydrodynamic parameters differ considerably. In conclusion, our data open the gate for the replacement of PEG by POx with the desirable absolute physicochemical properties adjusted quantitatively on a well-informed basis.


Mandy Grube
Friedrich Schiller University Jena
Additional Authors:
  • Prof. Dr. Ulrich S. Schubert
    Friedrich Schiller University Jena
  • Dr. Ivo Nischang
    Friedrich Schiller University Jena