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Oral Poster

Antibacterial functionalization of plasma-chemical oxidized titanium surfaces

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18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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Staphylococcus aureus is one the most clinical relevant pathogen in implant-associated infections. The aim of the present study was to develop antibacterial self-active implant surfaces with high biocompatibility.

Plasma-chemical oxidized titanium (TiOB) was functionalized with gentamicin-tannic acid (TiOB gta), silver nanoparticles (TiOB SiOx Ag) and ionic zinc (TiOB Zn) by different techniques. The antibacterial effect on Staph. aureus was determined by agar diffusion and proliferation test. Cytocompatibility was analyzed by direct contact test on MC3T3-E1 cells (2d, 4d).


All surfaces showed significant antibacterial activity. In the proliferation assay extended lag phases were observed (TiOB gta 5 h, TiOB SiOx Ag 8 h, TiOB Zn 10 h). TiOB gta and TiOB Zn samples showed significant bacterial suppression of Staph. aureus up to 48 h. In contrast, TiOB SiOx Ag was bactericidal for only 4 h. After cultivation for 4d vital MC3T3-E1 cells were observed on all surfaces.


The present study shows that functionalization of TiOB with gentamicin and ionic Zn is efficient in suppressing Staph. aureus. Further investigations are necessary to determine the efficiency of these surfaces also in-vivo.

 

Speaker:
Dr. Stefan Kranz
University Hospital Jena
Additional Authors:
  • Dr. Andre Guellmar
    University Hospital Jena
  • Dr. Juergen Schmidt
    INNOVENT e.V.
  • Silke Tonndorf-Martini
    University Hospital Jena
  • Dr. Michael Diefenbeck
    Schön Klinik Hamburg-Eilbek
  • Prof. Bernd Sigusch
    University Hospital Jena