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Oral Poster

Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge

Part of:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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One of the principal problems in the field of tissue engineering is to develop scaffolds that mimic the architecture of tissue at the nanoscale and have bioactivity properties.

The fibrous component of the extracellular matrix (ECM) in the tissue is made up of protein fibers such as collagens, elastin, keratin, laminins, fibronectin and vitronectin. The using of nanofibers consisted of a biodegradable polymers makes it possible to imitate the structure of the cellular matrix thereby creating comfortable conditions for cell adhesion and proliferation. We used polycaprolactone nanofibers because it has more suitable biodegradation time for biological application. However polycaprolactone is hydrophobic polymer and to improve biocompatibility of this material we covered nanofibers by COOH coating deposited by CO2/C2H4/Ar plasma polymerization.

Widely known that the in vivo bone bioactivity of a material can be predicted from the apatite formation on its surface in simulated body fluid (SBF). We investigated formation of Ca-containing layer on the surface of COOH modified PCL nanofibers and demonstrated high level biocompatibility and bioactivity by biological tests.

Fundamental processes behind plasma polymerization is studied through plasma diagnostics, as well as mass-spectroscopy and comprehensive surface analysis. The theoretical calculations are employed for better understanding of the surface reactions in the plasma polymer layers and for the characterization of the COOH grafting efficiency.


Ph.D. Elizaveta Permyakova
National University of Science and Technology MISiS
Additional Authors:
  • Dr. Anton Manakhov
    National University of Science and Technology MISiS
  • Dr. Phillip Kiruhancev-Korneev
    National University of Science and Technology MISiS
  • Dr. Natalya Gloushankova
    N.N. Blokhin Russian Cancer Research Centre of RAMS
  • Prof. Dr. Dmitry Shtansky
    National University of Science and Technology MISiS