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Oral Poster

Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration

Part of:
Line-Up:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

Session OP: Oral Poster Presentations
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M. Lietzow K. Besecke, R. Hinterding, L. Burmeister, A. Hoffmann, A. Kampmann, M. Stiesch, N. Ehlert


Bone replacement for defects after infection or cancer debridement are a critical problem in bone surgery. Autografts are still the materials of choice but have the disadvantage of low availability. Therefore, the aim of the presented work is the development of an easy to use biodegradable implant material which supports the formation of new bone in the long term.

In a first step nano- and macroporous bioactive glass scaffolds are produced via a sponge template method. A medical PU sponge is soaked with a precursor solution containing TEOS, as a silica source, ethanol, water, hydrochloric acid, calcium nitrate and F127 as structure directing agent. After coating and drying the initial sponge is removed together with the SDA by calcination at 600 °C [1]. For further improvement of the mechanical stability and to gain elastic be-haviour of the scaffolds these are coated with biodegradable polymers, like polytrimethylene carbonate and polyglyc-erol sebacate. The latter can be modified by a phosphate species in order to support bone formation. Current work is dedicated to incorporate more hydrophilic copolymers like poly ethylene glycol.

The materials are characterized via scanning and transmission electron microscopy, X-ray diffraction, sorption experi-ments, infrared spectroscopy and compression tests. Furthermore, biocompabitility is investigated via cytotoxicity tests.

The bioactive glass sponge replicas show nanopores of about 5 nm. The inner surface area was about 400 m2•g-1. The three-dimensonal open pore structure of the initial sponge template is well reproduced. The macropores show pore sizes in the range from 100 µm to about 600 µm. The polymer coating of the bioactive glass replicas lead to an improve-ment of the mechanical properties. The composites exhibit elastic mechanical behaviour. The developed multifunc-tional scaffolds are promising candidates for an effective bone replacement material.

[1] Shih C., Lu P., Chen W., Chang, Y., Chien C., Ceram. Int. 40 (2014) 15019.


 

Speaker:
Marvin Lietzow
Leibniz University Hannover
Additional Authors:
  • Karen Besecke
    Leibniz University Hannover
  • Richard Hinterding
    Leibniz University Hannover
  • Laura Burmeister
    Hannover Medical School (MHH)
  • Prof. Dr. Andrea Hoffmann
    Hannover Medical School (MHH)
  • Dr. Andreas Kampmann
    Hannover Medical School (MHH)
  • Prof. Dr. Meike Stiesch
    Hannover Medical School (MHH)
  • Dr. Nina Ehlert
    Leibniz University Hannover