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Oral Poster

Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems

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Line-Up:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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Biodegradable polymer nanoparticles (NPs) are of great interest for drug delivery systems due to their outstanding biocompatibility and easy preparation. The major challenge for these systems is to tailor their degradation and drug release to the application they are aimed for. It is reported that tuning the thermal properties (TPs) of polyesters via changing their crystallinity affects those properties but is also mostly accompanied by a variation of the hydrophilic / hydrophobic balance (HHB). This causes a knowledge gap on how the TPs of polymers affect their degradation and drug release without the influence of the HHB as third variable. In order to tackle that issue, our approach is to create novel polyester based NPs with different TPs, where the HHB is kept constant. Here we present first results of polymer synthesis and NP formation.

Polylactic acid (PLA) and a novel polymer “Poly Ethylene Glycolide” (PEtGly), with comparable structural features as PLA, as well as statistical copolymers PLA-co-EtGly with varying EtGly contents were synthesized by ring opening polymerization. Stereocomplexation was performed via casting method using tetrahydrofuran (THF). NPs in aqueous suspension were prepared by nanoprecipitation from THF into ultrapure water. The TPs were measured by differential scanning calorimetry (DSC). DLS was used to estimate the particle sizes of NPs and stereo complexes (SCs). NPs and SCs were characterized by AFM as well as with SEM and TEM. Pyrene fluorescence was used to determine the HHBs of PLA and PEtGly, which turned out to be the same. DSC measurements showed that the presence of EtGly significantly lowered both, the crystallinity of the copolymers compared to the homopolymers as well as the formation of SCs. AFM, SEM and TEM investigations of the NPs from copolymers, SCs and the bulk polymers consistently point towards a change of crystallinity induced by EtGly and an internal hollow structure of the NPs prepared via nanoprecipitation while the HHB is kept constant.

These polymeric NPs will lay the foundation for a new type of polymeric drug delivery systems which allows tailoring the degradation and release kinetics by changing their TPs.

This work is part of the Collaborative Research Center 1278: “Polytarget: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies” – project A06 which is funded by the Deutsche Forschungsgemeinschaft (DFG).

Speaker:
Karl Scheuer
Friedrich Schiller University Jena
Additional Authors:
  • Prof. Dr. Klaus D. Jandt
    Friedrich Schiller University Jena
  • Prof. Dr. Ulrich S. Schubert
    Friedrich Schiller University Jena
  • Dr. Christine Weber
    Friedrich Schiller University Jena
  • Damiano Bandelli
    Friedrich Schiller University Jena
  • Julien Alex
    Friedrich Schiller University Jena
  • Christian Helbing
    Friedrich Schiller University Jena