Oral Poster
Drug Delivery from Nanoporous Titania Coatings for Dental Application
Part of:Although tooth implants are a common treatment in dentistry nowadays, peri-implantitis remains a major health issue. Bacteria may form biofilms on the implants’ surface, caused by late infections, leading to high implant failure rates (>10%).[1,2] To prevent and cure these infections the bacteria have to be effectively eliminated shortly after implantation and biofilm formation has to be inhibited during the life-time of the implant. Thus, a controlled drug delivery system directly located on the implants’ surface offers a promising opportunity to accomplish the required antibacterial effect. A stimuli-response system is desired in order to ensure the release of an antibacterial drug if an infection occurs. Therefore, a nanoporous titania coating that can be attached to the implant surface seems to be suitable for both, the modification of the surface to introduce the stimuli-response effect as well as hosting of drug molecules. A similar system was already accomplished successfully for silica nanoparticles.[3] The first step to transfer the system to a titania surface was the establishment of nanoporous titania films by utilizing an adjusted cathodic electrodeposition method of Hu et al.[4] In a further step, the surface was modified with phosphonic acids, which form strong chemical bonds to titania.[5] The next step will be the attachment of a responding polymer employing a reaction route described by Menzel and co-workers.[6].
We were able to successfully attach different phosphonic acids to our electrodeposited titania surfaces. The modified and unmodified nanoporous titania films were examined by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), zeta-potential measurements and contact angle measurements (CA). Furthermore, first release experiments of a fluorescent dye from the coatings were performed.
References
[1] M.S. Tonetti et al., J. Clin. Periodontol. 2015, 42, 1–4.
[2] D. Cecchinato et al., Clin. Oral Implants Res. 2014, 25, 791–796.
[3] H. Fullriede et al., BioNanoMat 2016, 17, 59-72.
[4] C.-C. Hu et al, Electrochem. Commun. 2009, 11, 434.
[5] H. Zuilhof et al., Angew. Chem. 2014, 126, 6438-6474.
[6] H. Menzel et al., Langmuir 2004, 20, 26.
