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Oral Poster

Drug Delivery from Nanoporous Titania Coatings for Dental Application

Part of:
Line-Up:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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Although tooth implants are a common treatment in dentistry nowadays, peri-implantitis remains a major health issue. Bacteria may form biofilms on the implants’ surface, caused by late infections, leading to high implant failure rates (>10%).[1,2] To prevent and cure these infections the bacteria have to be effectively eliminated shortly after implantation and biofilm formation has to be inhibited during the life-time of the implant. Thus, a controlled drug delivery system directly located on the implants’ surface offers a promising opportunity to accomplish the required antibacterial effect. A stimuli-response system is desired in order to ensure the release of an antibacterial drug if an infection occurs. Therefore, a nanoporous titania coating that can be attached to the implant surface seems to be suitable for both, the modification of the surface to introduce the stimuli-response effect as well as hosting of drug molecules. A similar system was already accomplished successfully for silica nanoparticles.[3] The first step to transfer the system to a titania surface was the establishment of nanoporous titania films by utilizing an adjusted cathodic electrodeposition method of Hu et al.[4] In a further step, the surface was modified with phosphonic acids, which form strong chemical bonds to titania.[5] The next step will be the attachment of a responding polymer employing a reaction route described by Menzel and co-workers.[6].

We were able to successfully attach different phosphonic acids to our electrodeposited titania surfaces. The modified and unmodified nanoporous titania films were examined by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), zeta-potential measurements and contact angle measurements (CA). Furthermore, first release experiments of a fluorescent dye from the coatings were performed.


References

[1] M.S. Tonetti et al., J. Clin. Periodontol. 2015, 42, 1–4.

[2] D. Cecchinato et al., Clin. Oral Implants Res. 2014, 25, 791–796.

[3] H. Fullriede et al., BioNanoMat 2016, 17, 59-72.

[4] C.-C. Hu et al, Electrochem. Commun. 2009, 11, 434.

[5] H. Zuilhof et al., Angew. Chem. 2014, 126, 6438-6474.

[6] H. Menzel et al., Langmuir 2004, 20, 26.

 

Speaker:
Saskia Zailskas
Leibniz University Hannover
Additional Authors:
  • Philipp Abendroth
    Leibniz University Hannover
  • Prof. Dr. Meike Stiesch
    Hannover Medical School (MHH)
  • Prof. Dr. Peter Behrens
    Leibniz University Hannover