Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human bodyPart of:
An improve of the contrasting properties of polymer-based implants may be obtained by the preparation of mixtures of polymer (as a carrier) and contrast agent (CA). Polymers may carry various CAs in various concentrations what makes the implant visible in medical imaging. The possibility of adjusting the concentration or type of CAs may give additional possibility of differentiation of implants if appropriate segmentation will be applied. Additionally, the material composition may be optimized for visualization implants in many diagnostic techniques like e.g. X-rays based imaging, magnetic resonance-based imaging, NIR fluorescence imaging, ultrasound-based imaging.
The aim of this study was the development of two thermoplastic biodegradable composites containing the mineral present in the human body with contrasting properties in bimodal imaging (X-rays and NIR). The contrasting properties, degradation profile, and mechanical properties of the obtained composites were evaluated. Additionally, the new materials were tested in vivo.
The results obtained by wide range of analytical techniques suggest that the presented composites maybe used for both, X-rays and NIR imaging. The addition of the mineral results in positive changes in material microstructure and improved adhesion of cells during in vitro test. Moreover, preliminary in vivo results were also satisfactory.