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Oral Poster

A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum.

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Line-Up:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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Platinum is a commonly used electrode material within neuronal electrodes, e.g. the cochlear implant (CI). A reduction of the distance between spiral ganglion neurons and the platinum contacts of the CI would be favorable in order to obtain a higher signal resolution. This can be achieved by inducing dendrite growth towards the electrode by the release of neurotrophines or neuroprotective drugs from the electrode.[1]

Nanoporous platinum (NPPt) offers good electrochemical properties, a high surface area and good results within cell culture investigations. In order to accomplish a high drug loading we embodied nanoporous silica nanoparticles (NPSNPs) into the pore-system of the platinum. Those particles exhibit a large and permanent pore volume and, in contrast to platinum, a high versatility with regard to easily adjustable surface properties.[2,3]

A hard template approach was used, leading to the pore structure of the platinum, utilizing silica-polystyrene core-shell nanoparticles as template particles. After the electrochemical deposition of platinum, polystyrene was removed. SEM investigations showed the successful synthesis of the desired composition. Current work focuses on the characterization of this material and its biocompatibility.

This new hybrid material has the potential of combining the favorable properties of nanoporous platinum and nanoporous silica. Leading to a material with excellent electrochemical behavior simultaneously with a large pore volume and variety of possible surface modifications.

This work was supported by the DFG Cluster of Excellence EXC 1077/1 "Hearing4all".

Speaker:
Tim-Joshua Pinkvos
Leibniz University Hannover
Additional Authors:
  • Dr. Jennifer Schulze
    Hannover Medical School (MHH)
  • Valentin Hagemann
    Leibniz University Hannover
  • Hendrik Albert Schulze
    Leibniz University Hannover
  • Dawid Peter Warwas
    Leibniz University Hannover
  • Saskia Zailskas
    Leibniz University Hannover
  • Arne Schierz
    Leibniz University Hannover
  • Alexander Mohmeyer
    Leibniz University Hannover
  • Mandy Jahns
    Leibniz University Hannover
  • Kim Dana Kreisköther
    Leibniz University Hannover
  • Dr. Hans Christoph Schwarz
    Leibniz University Hannover
  • Dr. Athanasia Warnecke
    Hannover Medical School (MHH)
  • Prof. Peter Behrens
    Leibniz University Hannover