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Poster

Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s

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- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
- Poster Corrosion behaviour of potencially biodegradable ternary alloy Zn-Mg-Ca 1 Dipl.-Ing. Jan Pinc
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- Poster Cytotoxicity of gold nanorods and nanoribbons in context of biomedical applications 1 Marika Musielak
- Poster Preliminary studies of synthesis of gold nanoribbons using selected dicationic surfactants 1 Joanna Patalas
- Poster Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating 1 Prof. Ana Serro
- Poster Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s 1 Mengshi Yang
- Poster Influence of Cu2+-doping in β-TCP on the hydration kinetics of brushite cement investigated by Rietveld analysis and heat flow calorimetry 1 Karla Späth
- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
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- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
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- Poster Nano-rough titanium surfaces created by wet alkaline etching and PVD and their influence on bacterial adhesion as well as protein adsorption 1 Michaela Schürmann
- Poster Effective strategies for the controlling and dealing with transmission pathway of pathogens in air traffi 1 Christian Helbing
- Poster Cytotoxicity evaluation of biodegradable Zn-4Cu alloy using L929, Saos-2 and TAg cell lines 1 Ping Li
- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

Session P: Poster Session
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Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s

Mengshi Yang*, Robert Luxenhofer

Functional Polymer Materials, Chair for Chemical Technology of Material Synthesis and the Bavarian Polymer Institute, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany

mengshi.yang@uni-wuerzburg.de

 

Poly(2-oxazoline)s are regarded as a kind of pseudo-polypeptides, and considered to have potential biomedical applications, for instance, in drug delivery systems. We have synthesized a wide range of chiral poly(2,4-disubstituted-2-oxazoline)s via living cationic ring-opening polymerization, and investigated their water-solubility and optical activity as well as their thermal properties. Introduction of chirality via the alkyl substituents in the main chain in chiral poly(2,4-disubstituted-2-oxazoline)s allows for the formation of secondary structure in aqueous and non-aqueous environments as well as in bulk.[1-2] This will be interesting in the context of drug delivery, as shown by stereocomplexes using stereoregular poly(lactic acid). Therefore, drug loading with respect to chirality is being tested and will be reported.

 

References

1. Luxenhofer, R.; Huber, S.; Hytry, J.; Tong, J.; Kabanov, A. V.; Jordan, R., Chiral and Water-Soluble Poly(2-oxazoline)s. Journal of Polymer Science Part a-Polymer Chemistry 2013, 51 (3), 732-738.

2. Bloksma, M. M.; Rogers, S.; Schubert, U. S.; Hoogenboom, R., Main-Chain Chiral Poly(2-oxazoline)s: Influence of Alkyl Side-chain on Secondary Structure Formation in Solution. Journal of Polymer Science Part a-Polymer Chemistry 2011, 49 (13), 2790-2801.

Speaker:
Mengshi Yang
University of Würzburg