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Oral Poster

Thermal crosslinking of hydrophilic polymers using polyperoxides

Part of:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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Tissue engineering and regenerative medicine have attracted significant scientific interest [1] in recent years and material development in this area remains an important aspect. We require suitable materials and techniques which can help to create materials that can mimic mechanical properties and functions of the biological tissue. Hydrogels appear particularly suited as promising material class to deal with this difficult task [1-3]. New approaches to obtain hydrogels from new, simple and readily available building blocks are interesting to increase the molecular toolkit available to the materials engineer.

Here, we propose the possibility to crosslink functionalized as well as unfunctionalized hydrophilic polymers using polyperoxide copolymers [4]. This process is solvent free, can be carried out over a large range of temperatures, and allows to crosslink a large variety of different polymers.

To this end, novel copolymers, that contain peroxide groups in their side chains were synthesized and utilized to crosslink hydrophilic polymers with different molecular weight via recombination reaction of thermally activated free radicals of peroxide groups (Fig.1).

Figure 1. Simplified schematic illustration of peroxide containing copolymer induced cross-linking: (a) thermal decomposition of peroxide copolymer into two radicals when exposed to heat and then hydrogen abstraction from polymer chain by primary radical (b) and recombination reaction of polymer radicals (c).

We investigated the influence of crosslinker concentration, temperature as well as crosslinking time on swelling degree (SD) of the resulting hydrogels. The resulting SD is markedly depended mostly on polyperoxide concentration and temperature, while the curing time has only a minor effect on crosslinking process (Fig.2).

Figure 2. Influence of the peroxide containing copolymer concentration (10 - 20 wt.%), temperature (120-200 °C) and crosslinking time 10 – 40 min, on the swelling degree (SD) of PEtOx hydrogels. (A) - P[PM-co-MA] and (B) - P[PM-co-BA-co-MA].

In summary, we successfully crosslinked non-functionalized hydrophilic polymers and investigated the influence of crosslinking concentration, temperature and time on SD of resulting hydrogels. Variation parameters of the process can allow us to control the mechanical properties of an obtained materials.


Ph.D. Solomiia Borova
University of Würzburg
Additional Authors:
  • Prof. Dr. Robert Luxenhofer
    University of Würzburg
  • Prof. Dr. Viktor Tokarev
    Lviv Polytechnic National University