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Human Aorta under Tensile Stress

Thursday (09.05.2019)
09:40 - 10:00
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An aortic aneurysm constitutes a local enlargement of the aorta that is identified incidentally in most patients due to absence of symptoms. Prevalence of this disease strongly depends on age, gender and distinct risk factors, including smoking, overweight, hypertension and increased level of blood lipids. In case of an increasing aneurysm diameter, rupture within the aortic wall is an acute threat, the so called aortic dissection. At worst, rupture of the entire aorta arises, the so called aortic rupture. Within an interdisciplinary approach we investigate aortic samples from patients who suffer from an aortic aneurysm and underwent a surgery with regard to their mechanical properties. In doing so, tubular aortic portions were harvested from patients and cut into rectangular shapes, originated from convex, concave and longitudinal parts of the aorta, and stretched until rupture. Clinical data of patients as age, aortic diameter, arterial hypertension, elastin and collagen content or type of aortic valve (bicuspid- or tricuspid aortic valve) were correlated with the Young´s modulus to contribute to a better understanding of the role of pathological factors in mechanical properties of aorta.

Sabrina Friebe
Leipzig University
Additional Authors:
  • Dr. Josephina Haunschild
    Leipzig University
  • Prof. Christian Etz
    Leipzig University
  • Prof. Stefan Mayr
    Leipzig University