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Poster

Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties

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Line-Up:
- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
- Poster Corrosion behaviour of potencially biodegradable ternary alloy Zn-Mg-Ca 1 Dipl.-Ing. Jan Pinc
- Poster Multi scale topography in titanium alloys by electron beam technique: influence on the tissue adhesion and bacterial contamination 1 Dr. Fernando Warchomicka
- Poster Cytotoxicity of gold nanorods and nanoribbons in context of biomedical applications 1 Marika Musielak
- Poster Preliminary studies of synthesis of gold nanoribbons using selected dicationic surfactants 1 Joanna Patalas
- Poster Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating 1 Prof. Ana Serro
- Poster Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s 1 Mengshi Yang
- Poster Influence of Cu2+-doping in β-TCP on the hydration kinetics of brushite cement investigated by Rietveld analysis and heat flow calorimetry 1 Karla Späth
- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
- Poster Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations 1 Berit Karl
- Poster Graded functionalization of polydopamine coated fiber mats as potential implant for tendon-bone-transition 1 Sarah Oehmichen
- Poster Enhancing the functionalities of bioactive glass-based scaffolds by novel polymeric coatings 1 Dr. Liliana Liverani
- Poster Durability analysis of the cryopreservation of DNA origami nanostructures 1 Yang Xin
- Poster Effects of staple age on DNA origami nanostructure assembly and stability 1 Charlotte Kielar
- Poster Dual-setting brushite-silica gel cements – Variations of the monomer precursors and tuning of the setting parameters 1 Ib Holzmeister
- Poster Novel QCM-D/microscopy set-up for real-time analysis of bacterial binding onto biomaterial-coated sensors 1 Dr. Zeqian Xu
- Poster Chairside plasma activation of encapsulated implants: how fast is it? 1 Miguel Angel Garcia Chame
- Poster Nanostructured high-pressure laminate surfaces to reduce transmission pathways of pathogens in public transportation 1 Christian Helbing
- Poster Biomineralization of Recombinant Spider Silk Films 1 Vanessa J. Neubauer
- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
- Poster Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications 1 Mandy Grube
- Poster Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human body 1 Zaneta Górecka
- Poster Nano-rough titanium surfaces created by wet alkaline etching and PVD and their influence on bacterial adhesion as well as protein adsorption 1 Michaela Schürmann
- Poster Effective strategies for the controlling and dealing with transmission pathway of pathogens in air traffi 1 Christian Helbing
- Poster Cytotoxicity evaluation of biodegradable Zn-4Cu alloy using L929, Saos-2 and TAg cell lines 1 Ping Li
- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

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Bacterial cellulose (BC) is a biotechnologically derived nanostructured biopolymer with high potential in applications such as wound management or drug delivery systems [e.g. 1, 2]. It combines typical cellulose properties such as an excellent biocompatibility with the features of nanostructured materials, among them a high mechanical stability as well as a high liquid loading capacity.

In the InflammAging project, anti-inflammatory natural substances, such as triterpene acids from frankincense, are investigated as innovative active pharmaceutical ingredients. The most promising candidates are incorporated in BC-based wound dressings in order to treat local inflammatory wounds. However, the loading of BC with lipophilic substances is still challenging due to the hydrophilicity of the material. To overcome this challenge, achieving lipophilic drug incorporation and release, post- as well as in situ-modifications of the biopolymer during the bioprocess were investigated.

Native BC was synthesized by the bacteria strain Komagataeibacter xylinus at 28 °C in trays (20 x 20 cm) for seven days. For in situ-modification of the biopolymer BC during the cultivation in Hestrin-Schramm-medium different additives (e.g. with poly(ethylene glycol)) were tested. As a main result, pore sizes of the cellulose network could be varied in the range of 2-10 µm. Post-modification strategies focused on a hydrophobization of the nanostructured BC network in order to increase the uptake of lipophilic drugs. Results of the successful BC modification by acetylation or oxidation with 2,2,6,6-tetramethylpyperidine-1-oxyl (TEMPO) and subsequent conjugation with more hydrophobic compounds such as phenylalanine will be presented. An in-vitro toxicity test (MTT assay) proved preserved biocompatibility of the chemically modified biomaterial. In case of both, in-situ as well as post-modification, different loading capacities for anti-inflammatory model substances of varying lipophilicity (e.g. diclofenac & indomethacin) and release profiles could be observed. These findings are currently used for the incorporation of lipophilic frankincense extract, quantified by the lead substances 3-O-acetyl-11-keto-β-boswellic acid (AKBA) and 11-keto-β-boswellic acid (KBA) into BC for innovative product design based on highly promising natural compounds.


References:

[1] Sulaeva, I., et al., Biotechnol. Adv., 2015, 33(8): 1547-71.

[2] Mueller, A., et al., J. Pharm. Sci., 2013, 102(2): 579-592.

Speaker:
Uwe Beekmann
Friedrich Schiller University Jena
Additional Authors:
  • Paul Zahel
    Friedrich Schiller University Jena
  • Berit Karl
    Friedrich Schiller University Jena
  • Dr. Lisa Schmölz
    Friedrich Schiller University Jena
  • Prof. Dr. Stefan Lorkowski
    Friedrich Schiller University Jena
  • Prof. Dr. Oliver Werz
    Friedrich Schiller University Jena
  • Prof. Dr. Dagmar Fischer
    Friedrich Schiller University Jena
  • Dr. Dana Kralisch
    Friedrich Schiller University Jena