Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammationsPart of:
Bacterial nanocellulose (BNC), a biopolymer synthesized by the bacterial strain Komagataeibacter xylinus shows outstanding characteristics like excellent biocompatibility, high purity and extraordinary tensile strength. Its unique three-dimensional network of nanosized fibres facilitates drug delivery of various active substances and enables the BNC for medical applications like implants, tissue scaffolds or wound dressings . This study focussed on the incorporation of the anti-inflammatory frankincense extract into the BNC for the use as tailor-made wound dressing in dermal inflammations. Several loading techniques, excipients (like poly(ethylene glycol) and Poloxamers) or nanoemulsions were used to incorporate the lipophilic extract into the BNC. The influence on physicochemical and biological characteristics of the loaded BNC in dependency of the excipient and loading technique were investigated as well as the release and penetration behavior. Physicochemical characteristics like water absorption and retention of the BNC as well as mechanical stability could be modified by the different excipients and loading techniques. Release profiles and depth of skin penetration could be controlled by variation of the loading conditions. By combining the biopolymer BNC with natural frankincense extract we were able to obtain a natural drug delivery system with exceptional physicochemical and biological properties to develop an innovative dressing for inflamed wounds.
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