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Poster

Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations

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- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
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- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
- Poster Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations 1 Berit Karl
- Poster Graded functionalization of polydopamine coated fiber mats as potential implant for tendon-bone-transition 1 Sarah Oehmichen
- Poster Enhancing the functionalities of bioactive glass-based scaffolds by novel polymeric coatings 1 Dr. Liliana Liverani
- Poster Durability analysis of the cryopreservation of DNA origami nanostructures 1 Yang Xin
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- Poster Biomineralization of Recombinant Spider Silk Films 1 Vanessa J. Neubauer
- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
- Poster Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications 1 Mandy Grube
- Poster Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human body 1 Zaneta Górecka
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- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

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Bacterial nanocellulose (BNC), a biopolymer synthesized by the bacterial strain Komagataeibacter xylinus shows outstanding characteristics like excellent biocompatibility, high purity and extraordinary tensile strength. Its unique three-dimensional network of nanosized fibres facilitates drug delivery of various active substances and enables the BNC for medical applications like implants, tissue scaffolds or wound dressings [1]. This study focussed on the incorporation of the anti-inflammatory frankincense extract into the BNC for the use as tailor-made wound dressing in dermal inflammations. Several loading techniques, excipients (like poly(ethylene glycol) and Poloxamers) or nanoemulsions were used to incorporate the lipophilic extract into the BNC. The influence on physicochemical and biological characteristics of the loaded BNC in dependency of the excipient and loading technique were investigated as well as the release and penetration behavior. Physicochemical characteristics like water absorption and retention of the BNC as well as mechanical stability could be modified by the different excipients and loading techniques. Release profiles and depth of skin penetration could be controlled by variation of the loading conditions. By combining the biopolymer BNC with natural frankincense extract we were able to obtain a natural drug delivery system with exceptional physicochemical and biological properties to develop an innovative dressing for inflamed wounds.


References:

[1] Pötzinger, Y. et al.: Ther Deliv. 2017, 8 (9): 753-761.

[2] Alkhatib, Y. et al.: Eur J Pharm Biopharm. 2017, 112: 164-176.

Speaker:
Berit Karl
Friedrich Schiller University Jena
Additional Authors:
  • Yaser Alkhatib
    Friedrich Schiller University Jena
  • Uwe Beekmann
    Friedrich Schiller University Jena
  • Dr. Gabriele Blume
    Sopharcos
  • Dr. Dana Kralisch
    Friedrich Schiller University Jena
  • Prof. Dr. Oliver Werz
    Friedrich Schiller University Jena
  • Prof. Dr. Stefan Lorkowski
    Friedrich Schiller University Jena
  • Prof. Dr. Dagmar Fischer
    Friedrich Schiller University Jena