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Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations

Part of:
- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
- Poster Corrosion behaviour of potencially biodegradable ternary alloy Zn-Mg-Ca 1 Dipl.-Ing. Jan Pinc
- Poster Multi scale topography in titanium alloys by electron beam technique: influence on the tissue adhesion and bacterial contamination 1 Dr. Fernando Warchomicka
- Poster Cytotoxicity of gold nanorods and nanoribbons in context of biomedical applications 1 Marika Musielak
- Poster Preliminary studies of synthesis of gold nanoribbons using selected dicationic surfactants 1 Joanna Patalas
- Poster Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating 1 Prof. Ana Serro
- Poster Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s 1 Mengshi Yang
- Poster Influence of Cu2+-doping in β-TCP on the hydration kinetics of brushite cement investigated by Rietveld analysis and heat flow calorimetry 1 Karla Späth
- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
- Poster Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations 1 Berit Karl
- Poster Graded functionalization of polydopamine coated fiber mats as potential implant for tendon-bone-transition 1 Sarah Oehmichen
- Poster Enhancing the functionalities of bioactive glass-based scaffolds by novel polymeric coatings 1 Dr. Liliana Liverani
- Poster Durability analysis of the cryopreservation of DNA origami nanostructures 1 Yang Xin
- Poster Effects of staple age on DNA origami nanostructure assembly and stability 1 Charlotte Kielar
- Poster Dual-setting brushite-silica gel cements – Variations of the monomer precursors and tuning of the setting parameters 1 Ib Holzmeister
- Poster Novel QCM-D/microscopy set-up for real-time analysis of bacterial binding onto biomaterial-coated sensors 1 Dr. Zeqian Xu
- Poster Chairside plasma activation of encapsulated implants: how fast is it? 1 Miguel Angel Garcia Chame
- Poster Nanostructured high-pressure laminate surfaces to reduce transmission pathways of pathogens in public transportation 1 Christian Helbing
- Poster Biomineralization of Recombinant Spider Silk Films 1 Vanessa J. Neubauer
- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
- Poster Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications 1 Mandy Grube
- Poster Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human body 1 Zaneta Górecka
- Poster Nano-rough titanium surfaces created by wet alkaline etching and PVD and their influence on bacterial adhesion as well as protein adsorption 1 Michaela Schürmann
- Poster Effective strategies for the controlling and dealing with transmission pathway of pathogens in air traffi 1 Christian Helbing
- Poster Cytotoxicity evaluation of biodegradable Zn-4Cu alloy using L929, Saos-2 and TAg cell lines 1 Ping Li
- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

Session P: Poster Session
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Bacterial nanocellulose (BNC), a biopolymer synthesized by the bacterial strain Komagataeibacter xylinus shows outstanding characteristics like excellent biocompatibility, high purity and extraordinary tensile strength. Its unique three-dimensional network of nanosized fibres facilitates drug delivery of various active substances and enables the BNC for medical applications like implants, tissue scaffolds or wound dressings [1]. This study focussed on the incorporation of the anti-inflammatory frankincense extract into the BNC for the use as tailor-made wound dressing in dermal inflammations. Several loading techniques, excipients (like poly(ethylene glycol) and Poloxamers) or nanoemulsions were used to incorporate the lipophilic extract into the BNC. The influence on physicochemical and biological characteristics of the loaded BNC in dependency of the excipient and loading technique were investigated as well as the release and penetration behavior. Physicochemical characteristics like water absorption and retention of the BNC as well as mechanical stability could be modified by the different excipients and loading techniques. Release profiles and depth of skin penetration could be controlled by variation of the loading conditions. By combining the biopolymer BNC with natural frankincense extract we were able to obtain a natural drug delivery system with exceptional physicochemical and biological properties to develop an innovative dressing for inflamed wounds.


[1] Pötzinger, Y. et al.: Ther Deliv. 2017, 8 (9): 753-761.

[2] Alkhatib, Y. et al.: Eur J Pharm Biopharm. 2017, 112: 164-176.

Berit Karl
Friedrich Schiller University Jena
Additional Authors:
  • Yaser Alkhatib
    Friedrich Schiller University Jena
  • Uwe Beekmann
    Friedrich Schiller University Jena
  • Dr. Gabriele Blume
  • Dr. Dana Kralisch
    Friedrich Schiller University Jena
  • Prof. Dr. Oliver Werz
    Friedrich Schiller University Jena
  • Prof. Dr. Stefan Lorkowski
    Friedrich Schiller University Jena
  • Prof. Dr. Dagmar Fischer
    Friedrich Schiller University Jena