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Oral Poster

Degradable hybrid polymers for tissue engineering

Part of:
Line-Up:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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There are high demands on scaffold materials applied in the field of tissue engineering. For example, the medical field of bone regeneration requests a particular combination of properties like degradability, resorbability of degradation products by the human body, biocompatibility and a suitable Young’s modulus. Furthermore, the design of the produced scaffolds is very important as the cultivated cells need to invade and grow and thus give new bone regeneration. Individual shaping for a patient as well as establishing structures for nutrient and oxygen supply within the scaffold are basic requirements.

In order to conform to all these aspects a degradable and bioresorbable organic-inorganic hybrid polymer was developed. Due to the integration of hydrolytic and/or enzymatic cleavable groups in the organic part of the hybrid material, degradation is enabled. The organic curing of the inorganic pre-crosslinked resin is achieved by a Thiol-ene reaction with a crosslinking agent containing further cleavable groups. The radical Thiol-ene curing reaction can be initiated photochemically and therefore provides the opportunity to process the material in a 3D printer (DLP principle) and allows an individual multiform shaping. Since the material is assembled in a modular way modifications can be introduced simply. Hence the Young’s modulus already covers a range of 8 – 2100 MPa and can be adapted to a big variety of human tissue. The degradation rate depends on the hydrophilic properties of the underlying chemical structure. Therefore, various hybrid polymer systems show a mass loss within 16 weeks between 6 – 100 wt.% in a carbonate buffer solution. It was possible to observe the expected degradation products by 1H-NMR measurements.

 

Speaker:
Johannes Schwaiger
Fraunhofer Institute for Silicate Research ISC
Additional Authors:
  • Dr. Somchith Nique
    Fraunhofer Institute for Silicate Research ISC
  • Dr. Herbert Wolter
    Fraunhofer Institute for Silicate Research ISC