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Oral Poster

Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides

Part of:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

Session OP: Oral Poster Presentations
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Background: Hundreds of thousands of titanium dental and orthopaedic implants are inserted annually in the UK but around a fifth will fail prematurely, with bacterial infection being the principal cause within the first year. Implant infection leads to chronic complications and with the development of antimicrobial resistance, current antibiotic-based treatments are rapidly becoming ineffectual. With inspiration taken from nanotopography observed on insect wings that can physically induce bacterial cell death, this project seeks to replicate these effects on titanium and further enhance their bactericidal performance with antimicrobial peptides (AMPs).

Aims and objectives: This project aims to fabricate titanium surfaces with synergistic bactericidal capabilities mediated by nanostructures and antimicrobial peptides (recognised as potential alternatives to current antibiotics) that will successfully graft (osseointegrate) into bone. Objectives include:
1. Generate nanotopographies on the surface of titanium. 
2. Assess the bactericidal and anti-fouling potential of the surfaces using a variety of viability, metabolic and imaging assays.
3. Enhance and broaden the antimicrobial activity of the surfaces through coating with antimicrobial peptides.
4. Investigate the mechanical properties of the nanostructured surfaces and their correlation with osteogenic capabilities.

Results: Titanium dioxide nanostructures have been shown to cause a significant reduction in the vitality of Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae) and Gram-positive bacteria (Staphylococcus aureus). FIB-SEM performed at DESY has highlighted slight deformation of the Gram-negative bacterial cell membrane upon contact with the nanostructures. With AMP functionalisation complete inhibition of bacterial growth for 16 hours on flat surfaces but on nanostructures the AMP activity is impeded.

Significance of Research: This research promises to highlight methods of surface modification that could combat implant infections, and thus maximise the longevity of medical implants while minimising antibiotic use and maintaining osteogenic capabilities. This, in turn, could improve the wellbeing of millions of patients worldwide.

Marcus Eales
University of Bristol
Additional Authors:
  • Prof. Bo Su
    University of Bristol
  • Dr. Angela Nobbs
    University of Bristol
  • Dr. Wuge Briscoe
    University of Bristol
  • Dr. Maxime Ryadnov
    National Physical Laboratory (NPL)
  • Dr.-Ing. Thomas F. Keller
    Deutsches Elektronen-Synchrotron DESY