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Oral Poster

Nanostructured bone apatite-like thin films for bone prostheses

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Line-Up:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

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Calcium phosphates-based coatings have been extensively used to promote osseointegration of metallic implants. In particular, ion-doped hydroxyapatite thin films, having a composition as similar as possible to host bone, high adhesion to the substrate and surface roughness are desired.

Here, bone apatite-like thin films are proposed, manufactured by Ionized Jet Deposition, by ablation of deproteinized bone targets.

Previously, the Authors have proved the feasibility of the approach and the capability of bovine apatite coatings to promote host cells attachment, proliferation, differentiation, and their osteogenic commitment. Interestingly, coatings exhibited better mechanical and biological behavior compared stoichiometric hydroxyapatite.

Here, because the technique allows for a fine control over composition, different bone sources are used as deposition targets, and composition and morphology of the obtained coatings are compared (GI-XRD, FT-IR, SEM/EDS, AFM). Then, post-deposition annealing treatments (350-450°C) are proposed to optimize films crystallinity, hydrophilicity and adhesion (GI-XRD, contact angle, micro-scratch). Uniformity in deposition on complex geometries, such as bone screws and porous 3D-printed scaffolds is tested (SEM/EDS).

Coatings are primarily proposed for bone implants, but, because deposition occurs at room temperature, they can be of interest for several biomedical devices, including heat sensitive ones. For this reason, feasibility of deposition onto different polymers is demonstrated and possible damage caused to substrate morphology and composition is investigated (SEM/EDS, FT-IR, TGA).

All deposited coatings (≈450 nm thick) are composed of nano-sized globular aggregates and exhibit a nanostructured surface morphology. Thanks to nanostructuration and sub-micrometric thickness, substrate porosity and finishing at the micro-scale are preserved. Composition perfectly reflects that of deposition targets, also in terms of trace ions. Upon annealing at 400°C and above, crystallinity increases up to resembling that of bone, hydrophilicity increases and adhesion is optimized.

Finally, no damage is observed when coatings are deposited onto polymeric substrates, demonstrating the feasibility of the approach.

 

Speaker:
Dr. Gabriela Graziani
Rizzoli Orthopaedic Institute
Additional Authors:
  • Monica De Carolis
    Rizzoli Orthopaedic Institute
  • Dr. Michele Bianchi
    Rizzoli Orthopaedic Institute
  • Dr. Enrico Sassoni
    UniversitĂ  di Bologna
  • Matteo Berni
    Rizzoli Orthopaedic Institute
  • Dr. Alessandro Gambardella
    Rizzoli Orthopaedic Institute
  • Prof. Dr. Nicola Baldini
    Rizzoli Orthopaedic Institute