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Dual-setting brushite-silica gel cements – Variations of the monomer precursors and tuning of the setting parameters

Part of:
- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
- Poster Corrosion behaviour of potencially biodegradable ternary alloy Zn-Mg-Ca 1 Dipl.-Ing. Jan Pinc
- Poster Multi scale topography in titanium alloys by electron beam technique: influence on the tissue adhesion and bacterial contamination 1 Dr. Fernando Warchomicka
- Poster Cytotoxicity of gold nanorods and nanoribbons in context of biomedical applications 1 Marika Musielak
- Poster Preliminary studies of synthesis of gold nanoribbons using selected dicationic surfactants 1 Joanna Patalas
- Poster Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating 1 Prof. Ana Serro
- Poster Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s 1 Mengshi Yang
- Poster Influence of Cu2+-doping in β-TCP on the hydration kinetics of brushite cement investigated by Rietveld analysis and heat flow calorimetry 1 Karla Späth
- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
- Poster Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations 1 Berit Karl
- Poster Graded functionalization of polydopamine coated fiber mats as potential implant for tendon-bone-transition 1 Sarah Oehmichen
- Poster Enhancing the functionalities of bioactive glass-based scaffolds by novel polymeric coatings 1 Dr. Liliana Liverani
- Poster Durability analysis of the cryopreservation of DNA origami nanostructures 1 Yang Xin
- Poster Effects of staple age on DNA origami nanostructure assembly and stability 1 Charlotte Kielar
- Poster Dual-setting brushite-silica gel cements – Variations of the monomer precursors and tuning of the setting parameters 1 Ib Holzmeister
- Poster Novel QCM-D/microscopy set-up for real-time analysis of bacterial binding onto biomaterial-coated sensors 1 Dr. Zeqian Xu
- Poster Chairside plasma activation of encapsulated implants: how fast is it? 1 Miguel Angel Garcia Chame
- Poster Nanostructured high-pressure laminate surfaces to reduce transmission pathways of pathogens in public transportation 1 Christian Helbing
- Poster Biomineralization of Recombinant Spider Silk Films 1 Vanessa J. Neubauer
- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
- Poster Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications 1 Mandy Grube
- Poster Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human body 1 Zaneta Górecka
- Poster Nano-rough titanium surfaces created by wet alkaline etching and PVD and their influence on bacterial adhesion as well as protein adsorption 1 Michaela Schürmann
- Poster Effective strategies for the controlling and dealing with transmission pathway of pathogens in air traffi 1 Christian Helbing
- Poster Cytotoxicity evaluation of biodegradable Zn-4Cu alloy using L929, Saos-2 and TAg cell lines 1 Ping Li
- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

Session P: Poster Session
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Calcium phosphate cements (CPC) in general set via a dissolution–precipitation reaction of the cement raw materials. A further modification by adding monomers to the aqueous cement phase results in the formation of a second interpenetrating network with a strong impact on cement properties.[1] This was recently shown for cement modification with tetraethyl orthosilicate (TEOS) as precursor [2]. Here, this approach is further explored by using silica precursors with a higher density of alkoxy groups to increase network density in the final gel. The precursors were initially hydrolysed under acidic conditions and the combined with a brushite forming cement powder. Due to the increase in pH of the sol during cement setting leads to a simultaneous formation of cement matrix and silica hydrogel. Silica sols were obtained by adding a mixture of precursors (X = (100- 60%) TEOS and (0-40%) 1,2-Bis(triethoxysilyl)ethane or 1,8-Bis(triethoxysilyl)octane) to water and 0.1 M HCl solution. The influence of the water to alkoxy-group ratio (R) was also analyzed. Composite cements were produced by mixing the sol with cement raw powder, consisting of ß-tricalcium phosphate and anhydrous monocalciumphosphate in an equimolar ratio and the addition of 1 wt% citric acid (retarding agent). The results demonstrated an increase of mechanical performance by using a mixture of precursors in the composite compared to the pure TEOS reference. The porosity characteristics of the silica–brushite networks showed a bimodal pore size distribution in the set matrices with nanosized pores originating from the silica matrix and µm pores from the cement. The latter is thought to have a strong effect on drug release capability by retarding drug diffusion from the cement matrix.

[1] T. Christel et. al, Materials in Medicine, 2013, 24(3), pp 573-581

[2] M. Geffers et. al, Acta Biomaterialia, 2015, 11, pp 467-476

Ib Holzmeister
University Hospital Würzburg
Additional Authors:
  • Prof. Dr. Jürgen Groll
    University Hospital of Würzburg
  • Prof. Dr. Uwe Gbureck
    University Hospital of Würzburg