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Oral Poster

Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling

Part of:
Line-Up:
18:40 Oral Poster Effect of surface processing on roughness, wettability and cytotoxicity of carbon fiber-reinforced polyetheretherketone (PEEK) composite fabricated by fused deposition modeling 1 Dr. Xingting Han
18:43 Oral Poster Characterisation of bactericidal titanium surfaces using electron microscopy 1 Ph.D. Joshua Jenkins
18:49 Oral Poster Parvovirus B19 virus-like particles as platform for the development of biomaterials. 1 Prof. Dr. Ismael Bustos-Jaimes
18:52 Oral Poster The Influence of Surface Nanopatterns with varying Periodicities on Protein adsorption 1 Yu Yang
18:55 Oral Poster Opaque, Translucent and Transparent Flower Petals 1 Takumi Arakawa
18:58 Oral Poster Impact of Surface Morphology and Net Charge of Spider Silk based Materials on Interactions with Human Blood Components 1 Sarah Lentz
19:01 Oral Poster Modulation of Bacteria on Titanium Surfaces via Nanotopography and Antimicrobial Peptides 1 Marcus Eales
19:04 Oral Poster Degradable hybrid polymers for tissue engineering 1 Johannes Schwaiger
19:07 Oral Poster Antibacterial functionalization of plasma-chemical oxidized titanium surfaces 1 Dr. Stefan Kranz
19:10 Oral Poster Thermal crosslinking of hydrophilic polymers using polyperoxides 1 Ph.D. Solomiia Borova
19:13 Oral Poster Poly(peptoid)s: Peptidomimetics as potential Biomaterials 1 Christine Schlutt
19:16 Oral Poster A Nanoscaled Hybrid Coating for Neuronal Electrodes: Nanoporous Silica NPs Embodied into Nanoporous Platinum. 1 Tim-Joshua Pinkvos
19:19 Oral Poster Drug Delivery from Nanoporous Titania Coatings for Dental Application 1 Saskia Zailskas
19:22 Oral Poster Waste to resource: Biopolymer from industrial wastewater 1 Prof. Regina Nogueira
19:25 Oral Poster Divide and Comprehend: Separating the Effects of Hydrophobicity / Hydrophilicity and Crystallinity on the Thermal Properties of Polyester Based Drug Delivery Systems 1 Karl Scheuer
19:28 Oral Poster Elastic Polymer-Coated Nano- and Macroporous Bioactive Glass-Composites for Bone Regeneration 1 Marvin Lietzow
19:34 Oral Poster Alginate/silk fibroin-based hydrogels for vascularized tissue constructs 1 Dr. Raminder Singh
19:37 Oral Poster Diclofenac and moxifloxacin simultaneous delivery from intraocular lenses for endophthalmitis prophylaxis 1 Prof. Ana Serro
19:40 Oral Poster Optimization of a calcium phosphate based bone cement formulation 1 Prof. Dr. Rogério Cola?o
19:43 Oral Poster Nanostructured bone apatite-like thin films for bone prostheses 1 Dr. Gabriela Graziani
19:46 Oral Poster Low-dose BMP-2 enhances the bone-forming effects of an injectable, PLGA fiber-reinforced, brushite-forming cement in sheep lumbar osteopenia defects 1 Francesca Gunnella
19:49 Oral Poster The PLGA fiber component of brushite-forming calcium phosphate cement induces the osteogenic differentiation of human adipose tissue-derived stem cells 1 Francesca Gunnella
19:52 Oral Poster Surface functionalization of nanofibers by plasma processing in Ar/CO2/C2H4 discharge 0 Ph.D. Elizaveta Permyakova
19:55 Oral Poster Three-dimensional nanoscale X-ray computed tomography for the visualisation of cells grown on fibrous scaffolds 1 Dr. Juliana Martins de Souza e Silva

Session OP: Oral Poster Presentations
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Purpose:

Polyetheretherketone (PEEK) is increasingly used in oral and cranio-maxillofacial surgery as artificial implant material. In this study, we explored the influence of surface processing of fused deposition modeling (FDM) manufactured carbon fiber-reinforced polyetheretherketone (CFR-PEEK) on wettability, topography, and biocompatibility.


Materials and Methods:

PEEK composite reinforced by 5% carbon fibers (80-150 µm in length and 7 µm in diameter) were used to produce disk samples (14 mm diameter, 1 mm thickness) by FDM. The samples were divided into three groups, untreated, polished, and sandblasted (n = 12 per group). Topography and wettability were measured by profilometry and drop shape analysis. Cytotoxicity was tested according to ISO 10993-5:2009.

An extract test and a direct contact test were performed. Samples were extracted in cell culture medium for 24 h. L929 fibroblasts were subjected to extracts (24 h) and tested for inhibition of metabolic activity. For direct contact, cells were seeded directly onto the samples. After 24 h incubation, cell adhesion and viability were evaluated by LIVE/DEAD staining.


Results:

Untreated CFR-PEEK samples showed a rougher and more hydrophobic surface than polished and sandblasted ones. The extract test did not reveal any cytotoxic effects. Cell metabolic activity was comparable to the negative control group (Ti), even though after surface treatment some carbon fibers were exposed. After 24 h incubation in direct contact, it was observed that more cells attached to the untreated CFR-PEEK sample surfaces than to the treated samples. It was obvious, however, that the cells accumulated in the surface grooves resulting from the manufacturing process.


Conclusion:

1) No toxic substances were introduced during the FDM manufacturing process of CFR-PEEK.

2) Surface treatments leading to partial exposure of the fiber compound in the bulk material did not lead to increased cytotoxicity.

Speaker:
Dr. Xingting Han
University Hospital Tübingen
Additional Authors:
  • Dr. Chuncheng Yang
    Xi’an Jiaotong University
  • Dr. Sebastian Spintzyk
    University Hospital Tübingen
  • Dr. Lutz Scheideler
    University Hospital Tübingen
  • Prof. Dichen Li
    Xi’an Jiaotong University
  • Prof. Jürgen Geis-Gerstorfer
    University Hospital Tübingen
  • Prof. Frank Rupp
    University Hospital Tübingen