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Biomineralization of Recombinant Spider Silk Films

Part of:
- Plenary Lecture Test Ploetz 1 Alexia Ploetz
- Poster Investigating Dynamic Biological Processes with High-Speed, High-Resolution Correlative AFM-Light Microscopy 1 Oilibhe Pabsch
- Poster Corrosion behaviour of potencially biodegradable ternary alloy Zn-Mg-Ca 1 Dipl.-Ing. Jan Pinc
- Poster Multi scale topography in titanium alloys by electron beam technique: influence on the tissue adhesion and bacterial contamination 1 Dr. Fernando Warchomicka
- Poster Cytotoxicity of gold nanorods and nanoribbons in context of biomedical applications 1 Marika Musielak
- Poster Preliminary studies of synthesis of gold nanoribbons using selected dicationic surfactants 1 Joanna Patalas
- Poster Diclofenac release from a silicon based hydrogel for contact lenses controlled by a layer-by-layer coating 1 Prof. Ana Serro
- Poster Synthesis, solubility and optical activity of chiral poly(2,4-disubstituted-2-oxazoline)s 1 Mengshi Yang
- Poster Influence of Cu2+-doping in β-TCP on the hydration kinetics of brushite cement investigated by Rietveld analysis and heat flow calorimetry 1 Karla Späth
- Poster Analytical investigation of the influence of micro- and nanoplastic particles in crop plants by electron microscopic imaging and spectroscopy 1 Dr. Jörg Wissler
- Poster Influence of fluoride corrosion attack on the metal-porcelain bond strength of TiCr20 compared to titanium 1 Christine Schille
- Poster Bacterial nanocellulose loaded with frankincense extract as natural wound dressing to treat local dermal inflammations 1 Berit Karl
- Poster Graded functionalization of polydopamine coated fiber mats as potential implant for tendon-bone-transition 1 Sarah Oehmichen
- Poster Enhancing the functionalities of bioactive glass-based scaffolds by novel polymeric coatings 1 Dr. Liliana Liverani
- Poster Durability analysis of the cryopreservation of DNA origami nanostructures 1 Yang Xin
- Poster Effects of staple age on DNA origami nanostructure assembly and stability 1 Charlotte Kielar
- Poster Dual-setting brushite-silica gel cements – Variations of the monomer precursors and tuning of the setting parameters 1 Ib Holzmeister
- Poster Novel QCM-D/microscopy set-up for real-time analysis of bacterial binding onto biomaterial-coated sensors 1 Dr. Zeqian Xu
- Poster Chairside plasma activation of encapsulated implants: how fast is it? 1 Miguel Angel Garcia Chame
- Poster Nanostructured high-pressure laminate surfaces to reduce transmission pathways of pathogens in public transportation 1 Christian Helbing
- Poster Biomineralization of Recombinant Spider Silk Films 1 Vanessa J. Neubauer
- Poster Modification of bacterial cellulose to enhance anti-inflammatory wound dressing properties 1 Uwe Beekmann
- Poster Absolute Characterization of Synthetic Macromolecules used in Biomaterials Science Applications 1 Mandy Grube
- Poster Biodegradable thermoplastic materials for bimodal imaging containing the mineral present in the human body 1 Zaneta Górecka
- Poster Nano-rough titanium surfaces created by wet alkaline etching and PVD and their influence on bacterial adhesion as well as protein adsorption 1 Michaela Schürmann
- Poster Effective strategies for the controlling and dealing with transmission pathway of pathogens in air traffi 1 Christian Helbing
- Poster Cytotoxicity evaluation of biodegradable Zn-4Cu alloy using L929, Saos-2 and TAg cell lines 1 Ping Li
- Poster Influence of pulsed bias voltage on the tribological and morphological properties of a-C coatings deposited by an anodic arc method 1 Dipl.-Ing. Ingo Erdmann

Session P: Poster Session
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Among the great challenges of modern medicine is the regeneration of human tissue. In this context, functional materials can be tailored for biomedical applications inspired by the blueprint of the natural tissue. The production of hierarchically structured composite materials with biological function will need the incorporation of cells, biopolymers and inorganic components. Spider silk is a suitable candidate as a scaffold material as it shows no immunogenicity, good biocompatibility and biodegradability. Recently, we developed engineered recombinant spider silk proteins based on A. diadematus dragline silk, allowing tailoring these proteins already on a DNA level.1 This biopolymer can be easily processed into a variety of different morphologies, exemplary into hydrogels for 3D (bio)printing applications.2-4 The focus here is the incorporation of biominerals by various methods,5 yielding specialized scaffolds for tissue regeneration applications in terms of hard tissue development. The negatively charged spider silk variant eADF4(C16) displays multiple carboxylate moieties which are capable of binding cations.5 These charge dependent effects can be used to mineralize scaffolds in a post-treatment process. Further, the incorporation can be realized by seeding inorganic particles directly into a soft hydrogel matrix for 3D printing applications.


[1] Huemmerich, D.; Helsen, C. W.; Quedzuweit, S.; Oschmann, J.; Rudolph, R.; Scheibel, T., Biochemistry 2004, 43 (42), 13604-13612.

[2] Schacht, K.; Scheibel, T., Biomacromolecules 2011, 12 (7), 2488-2495.

[3] Schacht, K.; Juengst, T.; Schweinlin, M.; Ewald, A.; Groll, J.; Scheibel, T., Angew. Chem.-Int. Edit. 2015, 54 (9), 2816-2820.

[4] DeSimone, E.; Schacht, K.; Pellert, A.; Scheibel, T., Biofabrication 2017, 9 (4), 044104.

[5] Hardy, J. G.; Torres-Rendon, J. G.; Leal-Egana, A.; Walther, A.; Schlaad, H.; Coelfen, H.; Scheibel, T. R., Materials 2016, 9 (7).

Vanessa J. Neubauer
University of Bayreuth
Additional Authors:
  • Prof. Dr. Thomas Scheibel
    University of Bayreuth